GlutaredoxinV1, Main, Exploration, bibRecord, 000585

Zebrafish heart development is regulated via glutaredoxin 2 dependent migration and survival of neural crest cells.

Identifieur interne : 000585 ( Main/Exploration ); précédent : 000584; suivant : 000586

Zebrafish heart development is regulated via glutaredoxin 2 dependent migration and survival of neural crest cells.

Auteurs : Carsten Berndt [Allemagne] ; Gereon Poschmann [Allemagne] ; Kai Stühler [Allemagne] ; Arne Holmgren [Suède] ; Lars Br Utigam [Suède]

Source :

Redox biology [ 2213-2317 ] ; 2014.

RBID : pubmed:24944912

Descripteurs français

KwdFr :
- Animaux (MeSH), Apoptose (MeSH), Coeur (croissance et développement), Crête neurale (cytologie), Crête neurale (métabolisme), Danio zébré (croissance et développement), Développement embryonnaire (MeSH), Embryon non mammalien (métabolisme), Glutarédoxines (antagonistes et inhibiteurs), Glutarédoxines (génétique), Glutarédoxines (métabolisme), Interférence par ARN (MeSH), Mouvement cellulaire (MeSH), Myocarde (métabolisme), Petit ARN interférent (métabolisme), Protéines de poisson-zèbre (antagonistes et inhibiteurs), Protéines de poisson-zèbre (génétique), Protéines de poisson-zèbre (métabolisme).
MESH :
- antagonistes et inhibiteurs : Glutarédoxines, Protéines de poisson-zèbre.
- croissance et développement : Coeur, Danio zébré.
- cytologie : Crête neurale.
- génétique : Glutarédoxines, Protéines de poisson-zèbre.
- métabolisme : Crête neurale, Embryon non mammalien, Glutarédoxines, Myocarde, Petit ARN interférent, Protéines de poisson-zèbre.
- Animaux, Apoptose, Développement embryonnaire, Interférence par ARN, Mouvement cellulaire.

English descriptors

KwdEn :
- Animals (MeSH), Apoptosis (MeSH), Cell Movement (MeSH), Embryo, Nonmammalian (metabolism), Embryonic Development (MeSH), Glutaredoxins (antagonists & inhibitors), Glutaredoxins (genetics), Glutaredoxins (metabolism), Heart (growth & development), Myocardium (metabolism), Neural Crest (cytology), Neural Crest (metabolism), RNA Interference (MeSH), RNA, Small Interfering (metabolism), Zebrafish (growth & development), Zebrafish Proteins (antagonists & inhibitors), Zebrafish Proteins (genetics), Zebrafish Proteins (metabolism).
MESH :
- chemical , antagonists & inhibitors : Glutaredoxins, Zebrafish Proteins.
- chemical , genetics : Glutaredoxins, Zebrafish Proteins.
- cytology : Neural Crest.
- growth & development : Heart, Zebrafish.
- metabolism : Embryo, Nonmammalian, Glutaredoxins, Myocardium, Neural Crest, RNA, Small Interfering, Zebrafish Proteins.
- Animals, Apoptosis, Cell Movement, Embryonic Development, RNA Interference.

Abstract

Glutaredoxin 2 is a vertebrate specific oxidoreductase of the thioredoxin family of proteins modulating the intracellular thiol pool. Thereby, glutaredoxin 2 is important for specific redox signaling and regulates embryonic development of brain and vasculature via reversible oxidative posttranslational thiol modifications. Here, we describe that glutaredoxin 2 is also required for successful heart formation. Knock-down of glutaredoxin 2 in zebrafish embryos inhibits the invasion of cardiac neural crest cells into the primary heart field. This leads to impaired heart looping and subsequent obstructed blood flow. Glutaredoxin 2 specificity of the observed phenotype was confirmed by rescue experiments. Active site variants of glutaredoxin 2 revealed that the (de)-glutathionylation activity is required for proper heart formation. Our data suggest that actin might be one target during glutaredoxin 2 regulated cardiac neural crest cell migration and embryonic heart development. In summary, this work represents further evidence for the general importance of redox signaling in embryonic development and highlights additionally the importance of glutaredoxin 2 during embryogenesis.

DOI: 10.1016/j.redox.2014.04.012
PubMed: 24944912
PubMed Central: PMC4060141

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000618
to stream Main, to step Curation: 000618

Le document en format XML

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<author><name sortKey="Berndt, Carsten" sort="Berndt, Carsten" uniqKey="Berndt C" first="Carsten" last="Berndt">Carsten Berndt</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden ; Department of Neurology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Life Science Center, Merowinger Platz 1, Düsseldorf, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden ; Department of Neurology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Life Science Center, Merowinger Platz 1, Düsseldorf</wicri:regionArea>
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<author><name sortKey="Poschmann, Gereon" sort="Poschmann, Gereon" uniqKey="Poschmann G" first="Gereon" last="Poschmann">Gereon Poschmann</name>
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<author><name sortKey="Br Utigam, Lars" sort="Br Utigam, Lars" uniqKey="Br Utigam L" first="Lars" last="Br Utigam">Lars Br Utigam</name>
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<series><title level="j">Redox biology</title>
<idno type="ISSN">2213-2317</idno>
<imprint><date when="2014" type="published">2014</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Apoptosis (MeSH)</term>
<term>Cell Movement (MeSH)</term>
<term>Embryo, Nonmammalian (metabolism)</term>
<term>Embryonic Development (MeSH)</term>
<term>Glutaredoxins (antagonists & inhibitors)</term>
<term>Glutaredoxins (genetics)</term>
<term>Glutaredoxins (metabolism)</term>
<term>Heart (growth & development)</term>
<term>Myocardium (metabolism)</term>
<term>Neural Crest (cytology)</term>
<term>Neural Crest (metabolism)</term>
<term>RNA Interference (MeSH)</term>
<term>RNA, Small Interfering (metabolism)</term>
<term>Zebrafish (growth & development)</term>
<term>Zebrafish Proteins (antagonists & inhibitors)</term>
<term>Zebrafish Proteins (genetics)</term>
<term>Zebrafish Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Apoptose (MeSH)</term>
<term>Coeur (croissance et développement)</term>
<term>Crête neurale (cytologie)</term>
<term>Crête neurale (métabolisme)</term>
<term>Danio zébré (croissance et développement)</term>
<term>Développement embryonnaire (MeSH)</term>
<term>Embryon non mammalien (métabolisme)</term>
<term>Glutarédoxines (antagonistes et inhibiteurs)</term>
<term>Glutarédoxines (génétique)</term>
<term>Glutarédoxines (métabolisme)</term>
<term>Interférence par ARN (MeSH)</term>
<term>Mouvement cellulaire (MeSH)</term>
<term>Myocarde (métabolisme)</term>
<term>Petit ARN interférent (métabolisme)</term>
<term>Protéines de poisson-zèbre (antagonistes et inhibiteurs)</term>
<term>Protéines de poisson-zèbre (génétique)</term>
<term>Protéines de poisson-zèbre (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Glutaredoxins</term>
<term>Zebrafish Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glutaredoxins</term>
<term>Zebrafish Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Glutarédoxines</term>
<term>Protéines de poisson-zèbre</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Coeur</term>
<term>Danio zébré</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Crête neurale</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Neural Crest</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Heart</term>
<term>Zebrafish</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glutarédoxines</term>
<term>Protéines de poisson-zèbre</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Embryo, Nonmammalian</term>
<term>Glutaredoxins</term>
<term>Myocardium</term>
<term>Neural Crest</term>
<term>RNA, Small Interfering</term>
<term>Zebrafish Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Crête neurale</term>
<term>Embryon non mammalien</term>
<term>Glutarédoxines</term>
<term>Myocarde</term>
<term>Petit ARN interférent</term>
<term>Protéines de poisson-zèbre</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Apoptosis</term>
<term>Cell Movement</term>
<term>Embryonic Development</term>
<term>RNA Interference</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Apoptose</term>
<term>Développement embryonnaire</term>
<term>Interférence par ARN</term>
<term>Mouvement cellulaire</term>
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<front><div type="abstract" xml:lang="en">Glutaredoxin 2 is a vertebrate specific oxidoreductase of the thioredoxin family of proteins modulating the intracellular thiol pool. Thereby, glutaredoxin 2 is important for specific redox signaling and regulates embryonic development of brain and vasculature via reversible oxidative posttranslational thiol modifications. Here, we describe that glutaredoxin 2 is also required for successful heart formation. Knock-down of glutaredoxin 2 in zebrafish embryos inhibits the invasion of cardiac neural crest cells into the primary heart field. This leads to impaired heart looping and subsequent obstructed blood flow. Glutaredoxin 2 specificity of the observed phenotype was confirmed by rescue experiments. Active site variants of glutaredoxin 2 revealed that the (de)-glutathionylation activity is required for proper heart formation. Our data suggest that actin might be one target during glutaredoxin 2 regulated cardiac neural crest cell migration and embryonic heart development. In summary, this work represents further evidence for the general importance of redox signaling in embryonic development and highlights additionally the importance of glutaredoxin 2 during embryogenesis. </div>
</front>
</TEI>
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<DateCompleted><Year>2015</Year>
<Month>01</Month>
<Day>28</Day>
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<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
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<JournalIssue CitedMedium="Print"><Volume>2</Volume>
<PubDate><Year>2014</Year>
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<Title>Redox biology</Title>
<ISOAbbreviation>Redox Biol</ISOAbbreviation>
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<ArticleTitle>Zebrafish heart development is regulated via glutaredoxin 2 dependent migration and survival of neural crest cells.</ArticleTitle>
<Pagination><MedlinePgn>673-8</MedlinePgn>
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<Abstract><AbstractText>Glutaredoxin 2 is a vertebrate specific oxidoreductase of the thioredoxin family of proteins modulating the intracellular thiol pool. Thereby, glutaredoxin 2 is important for specific redox signaling and regulates embryonic development of brain and vasculature via reversible oxidative posttranslational thiol modifications. Here, we describe that glutaredoxin 2 is also required for successful heart formation. Knock-down of glutaredoxin 2 in zebrafish embryos inhibits the invasion of cardiac neural crest cells into the primary heart field. This leads to impaired heart looping and subsequent obstructed blood flow. Glutaredoxin 2 specificity of the observed phenotype was confirmed by rescue experiments. Active site variants of glutaredoxin 2 revealed that the (de)-glutathionylation activity is required for proper heart formation. Our data suggest that actin might be one target during glutaredoxin 2 regulated cardiac neural crest cell migration and embryonic heart development. In summary, this work represents further evidence for the general importance of redox signaling in embryonic development and highlights additionally the importance of glutaredoxin 2 during embryogenesis. </AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Berndt</LastName>
<ForeName>Carsten</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden ; Department of Neurology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Life Science Center, Merowinger Platz 1, Düsseldorf, Germany.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Poschmann</LastName>
<ForeName>Gereon</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Molecular Proteomics Laboratory, Heinrich-Heine-University, BMFZ, Düsseldorf, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stühler</LastName>
<ForeName>Kai</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Molecular Proteomics Laboratory, Heinrich-Heine-University, BMFZ, Düsseldorf, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Holmgren</LastName>
<ForeName>Arne</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bräutigam</LastName>
<ForeName>Lars</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden ; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.</Affiliation>
</AffiliationInfo>
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<Language>eng</Language>
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<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>05</Month>
<Day>02</Day>
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<MedlineTA>Redox Biol</MedlineTA>
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<ISSNLinking>2213-2317</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D054477">Glutaredoxins</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D034741">RNA, Small Interfering</NameOfSubstance>
</Chemical>
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<NameOfSubstance UI="D029961">Zebrafish Proteins</NameOfSubstance>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002465" MajorTopicYN="N">Cell Movement</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004625" MajorTopicYN="N">Embryo, Nonmammalian</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D047108" MajorTopicYN="N">Embryonic Development</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054477" MajorTopicYN="N">Glutaredoxins</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006321" MajorTopicYN="N">Heart</DescriptorName>
<QualifierName UI="Q000254" MajorTopicYN="Y">growth & development</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009206" MajorTopicYN="N">Myocardium</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009432" MajorTopicYN="N">Neural Crest</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D034622" MajorTopicYN="N">RNA Interference</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D034741" MajorTopicYN="N">RNA, Small Interfering</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015027" MajorTopicYN="N">Zebrafish</DescriptorName>
<QualifierName UI="Q000254" MajorTopicYN="Y">growth & development</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D029961" MajorTopicYN="N">Zebrafish Proteins</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">A, atrium</Keyword>
<Keyword MajorTopicYN="N">CCV, common cardinal vein</Keyword>
<Keyword MajorTopicYN="N">CNC, cardiac neural crest</Keyword>
<Keyword MajorTopicYN="N">Cardiac development</Keyword>
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Zebrafish heart development is regulated via glutaredoxin 2 dependent migration and survival of neural crest cells.

Zebrafish heart development is regulated via glutaredoxin 2 dependent migration and survival of neural crest cells.

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